Study: Cannabis Terpenoids “Exert Anti-Inflammatory and Antinociceptive Activities in Vitro and in Vivo”

Terpenoids derived from cannabis “exert anti-inflammatory and antinociceptive activities in vitro and in vivo”, according to a new study published by the National Institute of Health.

“Cannabinoids are well known to have anti-inflammatory effects in mammalians; however, the Cannabis plant also contains other compounds such as terpenoids, whose biological effects have not yet been characterized”, states the abstract of the study, which was conducted by researchers at The Hebrew University of Jerusalem.  With this in mind, the aim of this study “was to compare the anti-inflammatory properties of terpenoids with those of cannabidiol (CBD).”

For the study “Essential oils prepared from three monoecious nonpsychoactive chemotypes of Cannabis were analyzed for their terpenoid content and subsequently studied pharmacologically for their anti-inflammatory properties in vitro and in vivo.”

In vitro, “the three essential oils rich in terpenoids partly inhibited reactive oxygen intermediate and nitric oxide radical (NO•) production in RAW 264.7 stimulated macrophages.” The three terpenoid-rich oils “exerted moderate anti-inflammatory activities in an in vivo anti-inflammatory model without affecting tumor necrosis factor alpha (TNFα) serum levels.”

In their conclusion, researchers state that “The different Cannabis chemotypes showed distinct compositions of terpenoids. The terpenoid-rich essential oils exert anti-inflammatory and antinociceptive activities in vitro and in vivo, which vary according to their composition.”

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